Genomic identification of significant difference for DNA copy number profiles in tumor progression

Day & Time
17th July 2014, 15:10 ~
Venue
Room C816, Building of the Faculty of Science Graduate school of Science
Lecturer
Prof. Hiroko Kato Solvang (Institute of Marine Research, Norway)
Presentation Title
Genomic identification of significant difference for DNA copy number profiles in tumor progression
Abstract
Breast Cancer is heterogeneous disease both on the clinical and the molecular level. Our aim of this study is to compare array CGH DNA profiles of various stages of breast tumor as a surrogate of the course of tumorgenesis and identify significant aberrations that may be driving the process at each stage. For the challenge, applying GISTIC (Genomic Identification of Significant Targets in Cancer(2007)) to the data for each stage could identify likely driver somatic copy-number alterations (SCNA) by evaluating the frequency and amplitude of observed events. To directly identify significant difference for genome-wide copy number profiles in tumor progress, we propose a new approach of Genomic Identification Significant Difference for DNA copy number profiles in Tumor Progress (GISDIP).